Knoxville is a city in the U.S. state of Tennessee, and the county seat of Knox County. As of the 2010 census, the city had a population of 178,874, making it the state's third largest city. As of 2011, the city had an estimated population of 180,761. Knoxville is the principal city of the Knoxville Metropolitan Statistical Area, which in 2012 had an estimated population of 848,350. The KMSA is in turn the central component of the Knoxville-Sevierville-La Follette Combined Statistical Area, which in 2000 had a population of 1,029,155.